Little Clinical Relevance of Ca125, Cea and Ca125/Cea Ratio for the Differential Diagnosis of Ovarian and Non- Ovarian Carcinomatosis

Background In women, peritoneal cancer is commonly associated to epithelial ovarian cancer. Ovarian carcinomatosis patient survival appears be better in comparison other Malignancies, e.g., colorectal neoplasms or mesotheliomas. Here, we aim analyze the value of CA125, CEA, CA125/CEA ratio (CCR) tumor markers as preoperative tools for diagnosis Material and methods: From 2005-2008, recruit prospectively patients admitted Navarre Hospital Complex Gynecological service with suspicion origins. The final malignancies was obtained through Biopsy cytology. CA 125, CEA CCR were determined from venous blood Samples. We compared values between groups non-ovarian calculate receiver operating curves (ROC) CCR. Results 250 having carcinomatosis, only 86.4% Cases finally Sensitivities CA125 > 35 mg/dL, < 5 ngr/mL, 25 95.5%, 91.9%, 93.6% specificities 4.6%, 40.9% 40.0%, respectively. ROC displayed poor performance detecting (area under curve (AUC): 0.69 0.63, respectively) while analysis showed results (AUC: 0.74). Conclusions: somehow useful differentiate alone, although without sufficient specificity improving differential diagnosis.